Synthetic and Bioorganic Chemistry (SynBIOC)
SynBIOC provides a unique environment for innovative training of synthetic chemists in order to facilitate their integration into the ever-evolving world of interdisciplinary research at the Physical and Life Science interface. To achieve excellence in interdisciplinary research of this type, the hands-on and taught training activities maximise acquisition of expertise in the fields of organic synthesis, medicinal chemistry, spectroscopy, enzymology, biology and biotechnology.
Total synthesis of complex, pharmacologically-active, natural products and their analogues; medicinal chemistry (new anti-cancer, anti-AIDS, and anti-TB drugs); new methods for stereodefined alkene construction; chemical biology and use of small molecules to identify new biological targets; catalytic asymmetric synthesis and new chiral auxiliaries.
Enantioselective cascade sigmatropic rearrangements. Synthesis of spirocyclic ethers, spiroketals and spiroaminals. Synthesis of complex natural products. Atom-efficient transition metal catalysed coupling reactions.
Synthesis and study of natural products and biomaterials; biosynthetic origins; regulation of biological function.
Theoretical calculation and computer simulation of organic and biomolecular system. Interpretation and prediction of reaction mechanism and structure-based de novo drug design by theoretical methods and computer techniques.
Clean synthesis; microbial cis-dihydroxylation of aromatic systems; stereoselective sulfoxidation; systems which make use of clean oxidising agents; the industrial application of stereo-selective chemistry.
Synthesis of Bioactive Nitrogen Heterocycles.
Synthesis of biologically active naturally occurring Alkaloids and synthetic analogues. Asymmetric 1,3-dipolar cycloaddition reactions. Applications of transition metal activation of alkynes.
