Staff
- Academic Staff
- Dr M.N. Ahmad
- Professor S.J. Allen
- Professor S.E.J. Bell
- Professor D.R. Boyd
- Professor R. Burch OBE
- Dr M.J. Cook
- Professor A.P. de Silva
- Dr A.P. Doherty
- Dr N.C. Fletcher
- Dr A. Goguet
- Dr W. P.D.Goldring
- Professor K.J. Hale
- Professor C. Hardacre
- Dr J.D. Holbrey
- Professor P. Hu
- Dr M. Huang
- Dr. J. Jacquemin
- Professor S.L. James
- Dr M.C. Lagunas
- Dr I.C. Lane
- Dr W.F. Lin
- Professor T.R.A. Magee
- Dr P. Manesiotis
- Dr C. Mangwandi
- Professor J. Mann
- Dr H.G. Manyar
- Dr A.C. Marr
- Dr P.C. Marr
- Professor J.J. McGarvey
- Professor A. Mills
- Dr M.J. Muldoon
- Dr P. Nockemann
- Professor E.V. Rebrov
- Professor D.W. Rooney
- Professor K.R. Seddon
- Dr G.N. Sheldrake
- Dr P.J. Stevenson
- Dr K. Tchabanenko
- Dr J. Thompson
- Dr J.S. Vyle
- Professor G.M. Walker
- Dr P.J. Walsh
- All Staff
Dr M. Huang
Dr. Meilan Huang
BSc (Inner Mongolia University), 1995
MSc (Inner Mongolia University), 1998
PhD (Zhejiang University), 2003
Lecturer in Molecular Modelling
Tel: + 44 (0) 28 9097 4698
Fax: + 44 (0) 28 9097 6524
E-mail: m.huang@qub.ac.uk
Research Keywords
Theoretical calculationStructural-based drug design
Bioinformatics
Cheminformatics
The research in our group is focused on structural based drug lead discovery and optimization, computational prediction of protein structure and function, protein-ligand binding prediction, cheminformatics and theoretical calculation of chemical reactions in biological system. With broad collaboration with biologists, biochemists and medicinal chemists from academia and industry, the aim of our research is to identify anti-virus anti-bacterial, and anti-Cancer drug candidates.
Research
Developing algorithm in design novel peptides inhibitors
We have been developing new method to design inhibitors based on the target protein sequence and its structure feature in order to design inhibitors for class I and class II virus fusion proteins represented by influenza virus and Dengue virus. One undergoing case study in my group is Dengue 2 virus, the most prevalent of the four dengue serotypes.
Protein-ligand interaction
Discovery of specific USP17 inhibitors based on the structural difference of USP homologues
Protein-protein interaction
Protein-protein salt bridge interaction network identified in c-flip and FADD complex model
Protein structure-function relationship
Inherited mutation of R499C comprised the coordination of His502 to the heme reaction centre in myeloperoxidase
Radical reactions mechanism
Intramolecular H-atom transfer for radical cation of methionine in Alzheimer’s disease by theoretical calculations
Chemical enzymology in biological system
Active site base mechanism for galactokinase investigated using combined QM/MM
