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Professor Karl J. Hale

Karl Hale

Professor K.J. Hale
BSc (University of London), 1982
PhD (University of London), 1985

Director of Research, SynBIOC,
Chair of Organic and Medicinal Chemistry and Chemical Biology

Tel:     + 44 (0) 28 9097 5525
Fax:    + 44 (0) 28 9097 4687
E-mail: k.j.hale@qub.ac.uk

Enantioselective Formal Total Synthesis of the Dendrobatidae Frog Toxin, (+)-Pumiliotoxin B, Via O-Directed Alkyne Free Radical Hydrostannation
Manaviazar S, Hale KJ, and LeFranc A, Tetrahedron Letters (Harry Wasserman 90th Birthday Invitation Issue), 2010, doi:10.1016/j.tetlet.2010.10.141.
elsevier.com/retrieve/pii/S0040403910019532

 

090512-1

 

 

 

Total Synthesis of (+)-A83586C, (+)-Kettapeptin and (+)-Azinothricin: Powerful New Inhibitors of β-Catenin/TCF4-and E2FMediated Gene Transcription
Hale KJ, Manaviazar S and George J, Chem. Comm., 2010, 46, 4021-4042.
http://pubs.rsc.org/en/Content/ArticleLanding/2010/CC/c000603c

Total Synthesis of (+)-Azinothricin and (+)-Kettapeptin
Hale KJ, Manaviazar S, George JH, Walters MA and Dalby SM Org. Lett. 2009, 11, 733. http://pubs.acs.org/doi/abs/10.1021/ol802817t

090512-1

 

Molecules of the A83586C-Azinothricin-Kettapeptin and Agelastatin A Class; Their Synthesis, Mechanisms of Antitumour Action, and Potential for Counteracting β-Catenin Driven Cell Signalling
Hale KJ and Manaviazar S, J. Institute of Irish Chemistry (Irish Chemical News) 2009, 25 (2), 8-14.

 

 

Synthesis of A83586C Analogs with Potent Anticancer and E2F/b-Catenin/ TCF4/Osteopontin Inhibitory Effects and Insights Into How A83586C Modulates E2Fs and pRb
Hale KJ, Manaviazar S, Lazarides L, George J, Walters MA, Cai J, Delisser VM, Bhatia GS, Peak SA, Dalby SM, Lefranc A, Chen Y-NP, Wood A, Crowe P, Erwin P and El-Tanani M Org. Lett. 2009, 11, 737. http://pubs.acs.org/doi/abs/10.1021/ol802818f

090512-2

 

Pharmacological Actions of a New Synthetic Cyclodepsipeptide, the A83586C-Citropeptin Hybrid, on Complement C5a and G-Proteins
Assem E-SK, Peh KH, Wan BY, Manaviazar S, Walters MA, George JH, and Hale KJ Inflammation Res. 2008, 57, Supplement 1 (April 2008), 21-22.
http://www.springerlink.com/content/e186321qk51g1336/

 

A New Total Synthesis of the Marine Antitumor Alkaloid (-)-Agelastatin A
Domostoj MM, Irving E, Scheinmann F, and Hale KJ, Org. Lett., 2004, 6, 2615.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2004/6/i15/abs/ol0490476.html

Enantiospecific Formal Total Synthesis of the Antitumor and GSK-3β Inhibiting Alkaloid, (-)-Agelastatin A
Domostoj, M. Hale KJ, Tocher DA, Irving E, Scheinmann F, Org. Lett., 2003, 5, 2927.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2003/5/i16/abs/ol035036l.html

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Total Synthesis and Mechanism of Action Studies on the Antitumor Alkaloid (-)-Agelastatin A
Hale KJ, Domostoj MM, El-Tanani M, Campbell FC, Mason CK Strategies and Tactics in Organic Synthesis Vol. 6, Ed. M. Harmata, 2005, Chapter 11, 352.
http://129.35.76.177/wps/find/bookdescription.cws_home/706143/description#description

Agelastatin A: a Novel Inhibitor of Osteopontin-Mediated Adhesion, Invasion, and Colony Formation
Mason CK, McFarlane S, Johnston PG, Crowe P, Erwin PJ, Domostoj MM, Campbell FC, S. Manaviazar S, Hale KJ and El-Tanani M Molecular Cancer Therapeutics 2008, 7, 548-558 (March 1).
http://mct.aacrjournals.org/cgi/content/abstract/7/3/548

 

Asymmetric Total Synthesis and Formal Total Synthesis of the Antitumor Sesquiterpenoid, (+)-Eremantholide A
Li Y, Hale KJ, Org. Lett., 2007, 9, 1267.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2007/9/i07/abs/ol0700862.html

009

 

 

Enantiospecific Formal Total Synthesis of the Antitumor Macrolide Bryostatin 7
Manaviazar S, Frigerio M, Bhatia GS, Hummersone MG, Aliev AE, Hale KJ, Org. Lett., 2006, 8, 4477.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2006/8/i20/abs/ol061626i.html

A New Abridged Synthesis of the Masamune Bryostatin 7 “Southern Hemisphere” Intermediate
Hale KJ, Frigerio M, Manaviazar S, Org. Lett., 2003, 5, 503.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2003/5/i04/abs/ol027393m.html

001

 

A Short Synthetic Pathway to a Fully Functionalized Southern Hemisphere of the Antitumor Macrolide Bryostatin 1
Hale KJ, Frigerio M, Manaviazar S, Org. Lett., 2001, 3, 3791.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2001/3/i23/abs/ol016800b.html

New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides
Hale KJ and Manaviazar S, Chemistry: An Asian Journal, 2010, 5 (4), 704-754.
http://onlinelibrary.wiley.com/doi/10.1002/asia.200900634/abstract

 

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Synthesis of a Simplified Bryostatin C-Ring Analog That Binds to the CRD2 of Human PKC-, and Construction of a Novel BC-Analog By an Unusual Julia Olefination Process
Hale KJ, Frigerio M, Manaviazar S, Hummersone MG, Fillingham I, Barsukov I, Damblon C, Gescher A, Roberts GCK, Org. Lett., 2003, 5, 499.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2003/5/i04/abs/ol027392u.html

New Approaches to the Total Synthesis of the Bryostatin Antitumour Macrolides
Hale KJ and Manaviazar S, Chemistry: An Asian Journal, 2010, 5 (4), 704-754.
http://onlinelibrary.wiley.com/doi/10.1002/asia.200900634/abstract

The Chemistry and Biology of the Bryostatin Antitumour Macrolides
Hale KJ, Hummersone MG, Manaviazar S, Frigerio M, Nat. Prod. Rep. 2002, 413.
http://www.rsc.org/Publishing/Journals/NP/article.asp?doi=b009211h

 

A Biosynthetic Proposal for Ring Formation in the Antitumor Agent Halichomycin. Asymmetric Synthesis of the AB-Carbon Backbone of Halichomycin
Hale KJ, Dimopoulos P, Cheung MLF, Steed JW, and Levett PC Org. Lett., 2002, 4, 897.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2002/4/i06/abs/ol017266a.html

026

 

 

Synthetic Route to the GE3 Cyclodepsipeptide
Hale KJ, Lazarides L Org. Lett., 2002, 4, 1903.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2002/4/i11/abs/ol025895u.html

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Synthesis of an L-Proline Modified Mimetic of the A83586C Antitumour Cyclodepsipeptide
Hale KJ, Lazarides L, Chem. Commun. 2002, 1832.
http://www.rsc.org/Publishing/Journals/CC/article.asp?doi=b204018b

013

 

 

Total Synthesis of the Antitumour Antibiotic A83586C
Hale KJ, Cai J, Delisser VM, Manaviazar S, Bhatia GS, Peak SA, Tupprasoot R, Yeh L-K Proceedings of the Fourth Princess Chulabhorn International Science Congress; Chemicals in the 21st Century, Bangkok, Thailand (1999) 106. (Published in 2002)

Asymmetric Total Synthesis of Antitumour Antibiotic A83586C
Hale KJ, Cai J, Chem. Commun. 1997, 2319.
http://www.rsc.org.ezproxy.qub.ac.uk/Publishing/Journals/CC/article.asp?doi=a706206k

027

 

Total Synthesis of 4-Epi-A83586C. A Remarkable Epimerisation in A Macrolactamisation Mediated by BOP and DMAP",
Hale KJ, Cai J, and Williams G, SYNLETT 1998, 149.

 

O-Directed Free Radical Hydrostannations of Propargyl Ethers, Acetals and Alcohols with Ph3SnH and Et3B
Dimopoulos P, Athlan A, Manaviazar S, George J, Walters M, Lazarides L, Aliev AE, and Hale KJ, Org. Lett., 2005, 7, 5369.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2005/7/i24/abs/ol051936l.html

011

 

 

On the Stereospecific Conversion of Proximally Oxygenated Trisubstituted Vinylstannanes into Stereodefined Trisubstituted Alkenes
Dimopoulos P, Athlan A, Manaviazar S, Hale KJ, Org. Lett., 2005, 7, 5373.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2005/7/i24/abs/ol051935t.html

014

 

 

Mechanistic Studies on the O-Directed Free Radical Hydrostannation of Disubstituted Acetylenes with Ph3SnH and Et3B, and on the Iodination of Allylically Oxygenated α-Triphenylstannylalkenes
Dimopoulos P, George J, Manaviazar S, Tocher DA, Hale KJ, Org. Lett., 2005, 7, 5377.
http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2005/7/i24/abs/ol051937d.html

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Books